Hypotension after Anesthesia Induction: Target-Controlled Infusion Versus Manual Anesthesia Induction of Propofol

Background: Post-induction hypotension frequently occurs and can lead to adverse outcomes. As target-controlled infusion (TCI) obviates the need calculate rate manually helps safer dosing with prompt titration of drug using complex pharmacokinetic models, use TCI may provide a better hemodynamic profile during anesthesia induction. This study aimed compare versus manual induction determine risk factors for post-induction hypotension. Methods: A total 200 ASA grade 1–3 patients, aged 24 82 years, were recruited randomly assigned (n = 100) or groups 100). Hemodynamic parameters monitored pressure-recording analytic method. The propofol dosage was adjusted keep Bispectral Index between 40 60. Results: significantly higher in group than (34% vs. 13%; p < 0.001, respectively). dose did not differ (TCI: 155 (135–180) mg; manual: 150 (120–200) 0.719), but time longer (47 (35–60) s (105–220) s; In multivariable Cox regression model, presence hypertension, stroke volume index (SVI), cardiac power output (CPO), method found predict (p 0.032, 0.013, 0.024, 0.015, Conclusion: provided stability induction, decrease pre-induction SVI, CPO could